When I was trying our app, witch uses MapPoint, on VS2008 B2 I had some problems with it. Don't remember what it was exectly, don't have VS2008 right now, but it was becous off Data Execution Prevention enabled on VS process (actualy becous it prevented some MapPoint execution ), when I disabled DEP, all started to work as expected. I tryed it on Vista x64, and couldn't disable DEP on VS process, so I disabled it completly using bcdedit.