I have been using Manifold for about 2 years. Have previously depended on ArcView, MapInfo and SPANS(!).
Manifold has proved to be a powerful GIS tool for my work in Retail location and pipeline mapping.
I might add that MapPoint and Pushpin tools is an excellent set of tools to create data for Manifold operations. MapPoint is particularly useful for Canadian mapping as the digital files are very expensive here.
I would like to hear from anyone who has had success in accessing MapPoint data by using the Manifold geocoding extension. I have purchased this extension but so far the process is somewhat of a mystery to me.