I wrote a small C++ program to generate large poster size prints from MapPoint. It uses the Netpbm tools (Netpbm home page) to do all the work for me. Use cygwin (Cygwin Information and Installation) to install the Netpbm tools, but make sure you use the UNIX Default Text File Type as the window version coverts LF to CR-LF and messes up any binary input/output. The tool is a little hard coded, but I have tried to put comments around each code line and placed constants at the top. There is still a few changes that can be made to make it more user friendly (i.e., taking command line arguments instead of hard-coded, etc). Also, I'm sure someone can convert it to VBScript in less than an hour -- I am just more familiar with C++. One more thing, I convert the color map to gray scale as I am currently doing cheap b/w prints. Just take ppmtopgm out to not convert to gray scale.
The only thing I ask is if you make enhancements then post them so that everyone could use them. I hope people will find this useful.